Optimal Strategies for Sinusoidal Signal Detection

We derive and study optimal and nearly-optimal strategies for the detection of sinusoidal signals hidden in additive (Gaussian and non-Gaussian) noise. Such strategies are an essential part of algorithms for the detection of the gravitational Continuous Wave (CW) signals produced by pulsars. Optimal strategies are derived for the case where the signal phase is not known and the product of the signal frequency and the observation time is non-integral.Comment: 18 pages, REVTEX4, 7 figures, 2 table

New Frontiers: Catholic Social Teaching: What you need to know

Catholic social teaching is an essential and significant part of Catholicism. This lecture will address the roots of Catholic social teaching and narrate its development and the context of its development from Pope Leo XIII’s 1891 encyclical, RerumNovarum to Pope Francis’ 2015 encyclical Laudato Si’. It will suggest that Catholic social teaching has had three stages, the first emphasized justice, a second human dignity, and the third mercy and solidarity. Justice, dignity, and solidarity form then, the moral voice of Catholic social teaching. Dr. Brady has been a member of the St. Thomas Theology Department for thirty years. He served as department chair for 12 years and now, along with teaching, he is the Director of the Murray Institute for Catholic Education and is Associate Director of the Office of Mission. Dr. Brady has published six books, including Essential Catholic Social Thought, Be Good and Do Good, Christian Love, and A Spiritual Field Guide (with Mark Neuzil). He has authored a number of articles on Catholic social teaching and moral theology. Catholic social teaching is an essential and significant part of Catholicism. This lecture will address the roots of Catholic social teaching and narrate its development and the context of its development from Pope Leo XIII’s 1891 encyclical, RerumNovarum to Pope Francis’ 2015 encyclical Laudato Si’. It will suggest that Catholic social teaching has had three stages, the first emphasized justice, a second human dignity, and the third mercy and solidarity. Justice, dignity, and solidarity form then, the moral voice of Catholic social teaching. Dr. Brady has been a member of the St. Thomas Theology Department for thirty years. He served as department chair for 12 years and now, along with teaching, he is the Director of the Murray Institute for Catholic Education and is Associate Director of the Office of Mission. Dr. Brady has published six books, including Essential Catholic Social Thought, Be Good and Do Good, Christian Love, and A Spiritual Field Guide (with Mark Neuzil). He has authored a number of articles on Catholic social teaching and moral theology

Protection against Bordetella pertussis in mice in the absence of detectable circulating antibody: implications for long-term immunity in children

Most vaccines used for humans work through humoral immunity, yet many appear to be protective even after specific circulating antibody levels have waned to undetectable levels. Furthermore, it has been difficult to define a serologic correlate of protection against a number of infectious diseases, including those caused by Bordetella pertussis. B. pertussis clearance in immunized mice has been shown to correlate with pertussis vaccine efficacy in children. This murine respiratory challenge model was used to demonstrate persistent vaccine-induced protection against B. pertussis in the absence of circulating antibody at the time of challenge. Whole-cell and acellular pertussis vaccines induced persistent memory T and B cells and anamnestic antibody responses after challenge. The findings suggest that immunologic memory is more significant in protection than is the induction of immediate antibody responses and imply that vaccinated children still may be protected against disease following the disappearance of specific serum IgG

gamma-delta T Cells Regulate the Early Inflammatory Response to Bordetella pertussis Infection in the Murine Respiratory Tract

The role of T cells in the regulation of pulmonary inflammation following Bordetella pertussis infection was investigated. Using a well-characterized murine aerosol challenge model, inflammatory events in mice with targeted disruption of the T-cell receptor -chain gene (TCR mice) were compared with those in wild-type animals. Early following challenge with B. pertussis, TCR mice exhibited greater pulmonary inflammation, as measured by intra-alveolar albumin leakage and lesion histomorphometry, yet had lower contemporaneous bacterial lung loads. The larger numbers of neutrophils and macrophages and the greater concentration of the neutrophil marker myeloperoxidase in bronchoalveolar lavage fluid from TCR mice at this time suggested that differences in lung injury were mediated through increased leukocyte trafficking into infected alveoli. Furthermore, flow cytometric analysis found the pattern of recruitment of natural killer (NK) and NK receptor T cells into airspaces differed between the two mouse types over the same time period. Taken together, these findings suggest a regulatory influence for T cells over the early pulmonary inflammatory response to bacterial infection. The absence of T cells also influenced the subsequent adaptive immune response to specific bacterial components, as evidenced by a shift from a Th1 to a Th2 type response against the B. pertussis virulence factor filamentous hemagglutinin in TCR mice. The findings are relevant to the study of conditions such as neonatal B. pertussis infection and acute respiratory distress syndrome where T cell dysfunction has been implicated in the inflammatory process

Developing an enhanced 7-color multiplex IHC protocol to dissect immune infiltration in human cancers.

The TSA Opal multiplex immunohistochemistry (mIHC) protocol (PerkinElmer) has been used to characterize immune infiltration in human cancers. This technique allows multiple biomarkers to be simultaneously stained in a single tissue section, which helps to elucidate the spatial relationship among individual cell types. We developed and optimized two improved mIHC protocols for a 7-color panel containing 6 biomarkers (CD3, CD8, CD163, PD-L1, FoxP3, and cytokeratin (CK)) and DAPI. The only difference between these two protocols was the staining sequence of those 6 biomarkers as the first sequence is PD-L1/CD163/CD8/CK/CD3/FoxP3/DAPI and the second sequence is FoxP3/CD163/CD8/CK/CD3/PD-L1/DAPI. By comparing PD-L1/FoxP3 staining in mIHC and singleplex PD-L1/FoxP3 staining on the adjacent slide, we demonstrated that the staining sequence does not affect the staining intensity of individual biomarkers as long as a proper antigen retrieval method was used. Our study suggests that use of an antigen retrieval buffer with higher pH value (such as Tris-EDTA pH9.0) than that of the stripping buffers (such as citrate buffer pH6.0) is helpful when using this advanced mIHC method to develop panels with multiple biomarkers. Otherwise, individual biomarkers may exhibit different intensities when the staining sequence is changed. By using this protocol, we characterized immune infiltration and PD-L1 expression in head and neck squamous cell carcinoma (HNSCC), breast cancer (BCa), and non-small cell lung cancer (NSCLC) specimens. We observed a statistically significant increase in CD3+ cell populations within the stroma of NSCLC as compared to BCa and increased PD-L1+ tumor cells in HNSCC as opposed to BCa

Resource Planning for Neglected Tropical Disease (NTD) Control Programs: Feasibility Study of the Tool for Integrated Planning and Costing (TIPAC).

<p>Resource Planning for Neglected Tropical Disease (NTD) Control Programs: Feasibility Study of the Tool for Integrated Planning and Costing (TIPAC)</p

A Year of Wavefront Sensing with JWST in Flight: Cycle 1 Telescope Monitoring and Maintenance Summary

We summarize JWST's measured telescope performance across science Cycle 1. The stability of segments alignments is typically better than 10 nanometers RMS between measurements every two days, leading to highly stable point spread functions. The frequency of segment "tilt events" decreased significantly, and larger tilt events ceased entirely, as structures gradually equilibrated after cooldown. Mirror corrections every 1-2 months now maintain the telescope below 70 nm RMS wavefront error. Observed micrometeoroid impacts during cycle 1 had negligible effect on science performance, consistent with preflight predictions. As JWST begins Cycle 2, its optical performance and stability are equal to, and in some ways better than, the performance reported at the end of commissioning.Comment: STScI Technical Memo. 2.5 pages text, 1 figur